NGAL FOR DIAGNOSING ACUTE KIDNEY INJURY

laboNGAL is a new biomarker for the diagnosis of acute kidney insufficiency or according to the terminology accepted abroad, acute kidney injury (AKI). The main advantage of NGAL is the earliest increase in its concentration in the development of acute kidney insufficiency, especially when compared with other renal markers. At the same time, the increase in the level of NGAL is proportional to the severity of developing kidney injury. Thus, NGAL allows early diagnostics and stratification of risks in the development of acute renal injury and makes possible the timely application of preventive therapy. Early diagnosis of acute kidney insufficiency allows making clinical decisions in the shortest time before the onset of acute kidney insufficiency and making proactive measures to stop declining kidney function.

Clinical application. AKI occurs in about 5% of all hospitalized patients; over 30% of patients in intensive care units may have some degree of acute kidney insufficiency, which increases comorbidity and mortality. Such a diagnostic method, as measuring the level of creatinine in blood serum, reflects only the condition that have developed after the injury of renal functions, which can appear in a day or more after the initial kidney injury. With help of this analysis, attending physicians will be able to begin appropriate AKI treatment within few hours, not days after kidney injury.

Application field:

Intensive care units (ICU). Timely monitoring of patient in ICU, where, according to statistics, the risk of the development of AKI reaches 50%, especially in patients with sepsis or multiple trauma and significant blood loss. The use of NGL as an indicator of risk of developing AKI for screening patients in ICU provides early prevention of such a serious complication and sharply increases the likelihood of a successful outcome.

Emergency care. NGAL is a fast and highly specific marker of AKI for primary screening of patients admitted to emergency departments with unknown diagnosis.

Surgery with using CPB (Cardiopulmonary bypass). The monitoring of the level of NGL after surgery timely predicts the development of acute kidney injury caused by renal ischemia due to CPB.

Application of radiopaque preparations. The monitoring of the level of NGL indicates nephrotoxicity and development of AKI caused by the use of radiocontrast preparations.

Kidney transplantation. Post transplantations levels of NGAL provide a clear prediction of the function and survival rate of the transplant.

Heart- liver transplantation. Determination of the postoperative level of NGAL allows timely find out and prevent renal complications.

Currently, this analysis you can pass in the laboratory of a private medical center “MedServis”

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