Incidence of renal replacement therapy (RRT) in the diabetic compared with the non-diabetic population in a German region, 2002–08

6e8ebcbdb7dfa12d1fa56e0a9ec820d6Andrea Icks, Burkhard Haastert, Jutta Genz, Guido Giani, Falk Hoffmann, Rudolf Trapp, Michael Koch

Background.

This study was conducted to estimate incidences of renal replacement therapy (RRT) in the diabetic and non-diabetic populations in Germany.

Methods.

Using the data of a regional dialysis centre (region population of 310 000), we assessed all incident RRT patients aged 30 years or older in 2002–08.

Results.

Of all subjects with incident RRT (n = 544), 49.6% had diabetes. Fifty-eight percent were male, mean age (SD) was 70.3 years (11.4 years). Incidences per 100 000 person-years (standardized to the 2004 German population) in the diabetic and the non-diabetic populations were 213.7 [95% confidence interval (95% CI), 159.5–267.8] and 26.9 (95% CI, 22.5–31.3) in men and 130.2 (95% CI, 65.6–194.9) and 16.4 (95% CI, 13.5–19.3) in women, respectively. Standardized relative risks were 7.9 (5.9–10.8) in men and 8.0 (4.7–13.5) in women. There was a significant interaction between age and diabetes, with lower relative risks in higher ages. Attributable risks among diabetic individuals were 0.87 in men and women, and population-attributable risks were 0.41 and 0.35 in men and women, respectively.

Conclusions.

In this population-based study in a German region, we found the relative risk of RRT in the estimated adult diabetic population to be 8-fold increased compared with the non-diabetic population. A high proportion of the RRT risk can be attributed to diabetes in the diabetic as well as in the whole population.

 

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